Muscular dystrophy Treatment

   

Muscular dystrophy Information

These progressive genetically determined disorders of skeletal and sometimes cardiac muscle have a complex clinical and neurogenetic classification.


Clinical features of Muscular dystrophy

The boy with DMD is noticed to have difficulty in running and in rising to an erect position from the floor, when he has to use the hands to climb up his legs (Gowers' sign). There is initially a proximal limb weakness with pseudohypertrophy of the calves. The myocardium is affected. The boy becomes severely disabled by the age of 10.

Muscular dystrophy symptom

Types of Muscular dystrophies

  1. Duchennes Muscular dystrophy (DMD)
  2. Becker's muscular dystrophy
  3. Limb girdle muscular dystrophy (LGMD)
  4. Facioscapulohumeral muscular dystrophy
  5. Myotonic muscular dystrophy
  6. Congenital muscular dystrophy

Diagnosis of Muscular dystrophy

Diagnosis is often made on clinical grounds alone. Creatine phosphokinase is grossly elevated (100-200 times normal). Muscle biopsy shows characteristic variation in fibre size, fibre necrosis, regeneration and replacement by fat, and on immunochemical staining an absence of dystrophin. EMG shows a myopathic pattern.

Treatment and management of Muscular dystrophy

There is no curative treatment. Passive physiotherapy helps to prevent contractures in the later stages of the disease. Portable respiratory support gives a substantially improved life expectancy.

Carrier detection. A female with an affected brother has a 50% chance of carrying the gene. In carrier females, 70% have a raised creatine phosphokinase level and the remainder usually have electromyographic abnormalities or changes on biopsy. Accurate carrier and prenatal diagnosis can be made using cDNA probes that are co-inherited with the DMD locus.

Genetic advice and counselling about possible termination of pregnancy should be given. Determination of fetal sex by amniocentesis and selective abortion of a male fetus is sometimes carried out. Many proven carrier females choose not to have offspring.

Vitamin E








 

Share |

Related Articles on Deficiency Diseases

  Hemochromatosis
  Siderosis
  Anemia
  Thalassemia
  Sideroblastic anemia
  Porphyria cutanea tarda
  Sickle-cell anemia
  Wilsons Disease
  kwashiorkor
  Menkes syndrome
  Neutropenia
  Keratomalacia
  Xerophthalmia
  Prophylaxis
  Rhodopsin
  Bitot's spots
  Beriberi
  Pellagra
  Macrocytic anemia
  Megaloblastic anemia
  Pernicious anemia
  Scurvy
  Rickets
  Osteomalacia
  Abetalipoproteinemia
  Muscular dystrophy
  Haemolytic anaemia
  Cholestatic Jaundice Constipation
  Myxedema
  Cretinism
  Hypothyroidism
  Hypothyroidism symptom
  Losing weight with hypothyroidism
  Subclinical hypothyroidism
  Congenital hypothyroidism
  Hashimotos thyroiditis
  Postpartum thyroiditis
  Hyperthyroidism
  Hyperthyroidism symptom
  Feline hyperthyroidism
  Graves disease
  Thyrotoxicosis
   Plummer's disease
  Thyroid storm
  Fluorosis
  Acrodermatitis enteropathica
  Metal fume fever
  Keshan disease
Metabolic Syndrome

Nutrition - Vitamins | Amino Acids | Herbs | Minerals | Nutrients | Supplements | Enzymes
Wellness - Healthy Living | Dental Care | Products | Skin Vitamins | Ayurveda | Slideshow
Health - Deficiency | Alternative Medicines | How To | Symptoms | Food Kitchen How tos?
Fitness - Exercises | Gardening
Food & Cooking - Recipes | Fruits & Vegetables
Healthy Eating & Diet - Diet | Weight Loss | Green Tea | Noni Juice | Acai
Online Vitamins Guide

Nutrition Articles | Your Feedback & Suggestions | Newsletter
Disclaimer | Blog
Home © 2001-2013 online-vitamins-guide.com. All rights reserved.