Skin and tissue disorder usually due to hypothyroidism
Pretibial Myxedema (PTM)
Pretibial Myxedema is an uncommon complication of Grave's disease, occurring in 1-4% of patients. There is a diffuse, non-pitting edema and thickening of the skin usually on the anterior aspect of the lower legs spreading to the dorsum of the feet.
Myxedema Coma
Myxedema coma, the extreme manifestation of hypothyroidism, is an uncommon but potentially lethal condition. Patients with hypothyroidism may exhibit a number of physiologic alterations to compensate for the lack of thyroid hormone.
Symptoms of Myxedema
weakness
fatigue
cold intolerance
Constipation
weight gain (unintentional)
depression
joint or muscle pain
thin, brittle fingernails
thin and brittle hair
paleness
Hypothyroidism, or underactivity of the thyroid gland, may cause a variety of symptoms and may affect all body functions. The body's normal rate of functioning slows, causing mental and physical sluggishness. The symptoms may vary from mild to severe, with the most severe form called myxedema, which is a medical emergency.
Treatment of Myxedema
Levothyroxine (T4) replacement. In elderly individuals, the starting dose should be low and increased slowly, so as not to precipitate any underlying heart disease.
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