Plummer's disease - Toxic solitary adenoma/nodule


Also called Parry's disease. Plummer's disease is the cause of about 5% of cases of hyperthyroidism. It does not usually remit after a course of antithyroid drugs. Plummer's condition characterized by marked enlargement of the thyroid gland (goitre), firm thyroid nodules, and mild overproduction of thyroid hormone.

Plummer's disease, which usually occurs in older people, is of unknown etiology. Its symptoms resemble those of Graves' disease, a condition believed to be an autoimmune disorder.

Also known as Graves' disease, thyrotoxicosis, toxic diffuse goiter, toxic nodular goiter and Basedow's disease. Hyperthyroidism is a condition marked by excessive production of thyroid hormones that results in multiple-system abnormalities ranging from mild to severe hormonal imbalances.

The physical examination may reveal a rapid and/or irregular heart beat, warm, thin, moist skin over most of the body. Other physical signs which can occur in certain people are eyelid lag, eyelid retraction, abnormal bulging of the eyes and increased tearing. Women may present with irregular periods, increased vaginal bleeding or compete cessation of menstruation as the only obvious symptom. This often causes a perpetual "startled look" appearance.




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